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2010 Fiscal Year Final Research Report

Development of catalytic carbon-carbon-bond formation reactions and their application to analysis of pesticide residues

Research Project

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Project/Area Number 20550137
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental chemistry
Research InstitutionToyohashi University of Technology

Principal Investigator

IWASA Seiji  Toyohashi University of Technology, 大学院・工学研究科, 准教授 (30303712)

Project Period (FY) 2008 – 2010
Keywordsハプテン / 免疫化学測定法 / 抗原抗体反応 / 残留農薬触媒反応 / ELISA / イムノアッセイ / エマメクチン / アゾキシストロビン
Research Abstract

We developed a novel catalyst for carbon-carbon bond formation and successfully applied it for analysis of insecticide residues in agricultural products by a prepared mouse monoclonal antibody using enzyme-linked immunosorbeninsectitide residuest assay (ELISA). The working range was ppm-ppb level. The assay was sufficiently sensitive for analysis of the maximum residue limits in agricultural products in Japan. Our results indicate that the system we developed was useful for analysis of insecticide residues in agricultural products because rapid operation, highly accurate, flexible mobility, cheap, environmentally friendly system so on. The kits are now commercially available.

  • Research Products

    (18 results)

All 2010 2009 2008 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (8 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Ru(II)-and Ir(I) Catalyzed Hydrogen Peroxide Oxidation of Hydroxamic Acids and their Subsequent Hetero Diels-Alder Cycloadditions with Chiral N-Dienyl Lactams2010

    • Author(s)
      Ahmad Fakhruddin, Kesiny Phomkeona, Abdel-Moneim Abu-Elfotoh, Kazutaka Shibatomi, Seiji Iwasa
    • Journal Title

      Letters in Organic Chemistry 7

      Pages: 475-478

    • Peer Reviewed
  • [Journal Article] Asymmetric Inter-and Intramolecular Cyclopropanation Reactions Catalyzed by a Reusable Macroporous-Polymer-Supported Chiral Ruthenium(II)/Phenyloxazoline Complex2010

    • Author(s)
      Abdel-Moneim Abu-Elfotoh, Kesiny Phomkeona, Kazutaka Shibatomi, Seiji Iwasa
    • Journal Title

      Angew.Chem.Int.Ed. 49

      Pages: 8439-8443

    • Peer Reviewed
  • [Journal Article] Development of an Enzyme-Linked Immunosorbent Assay for Residue Analysis of the Insecticide Emamection Benzoate in Agricultural Products2009

    • Author(s)
      Kondo, M., Yamashita, H., Uchigashima, M., Kono, T., Takemoto, T., Fujita, M., Saka, M., Iwasa, S,, Ito, S., Miyake, S.
    • Journal Title

      Journal of Agricultural and Food Chemistry 57

      Pages: 359-364

    • Peer Reviewed
  • [Journal Article] Design and Synthesis of Novel Molecular Ru(II) Catalyst and its Applications to Highly Active Carbene Insertion Reactions of Diazo Ester2009

    • Author(s)
      Phomkeona, K., Nguyen M.N., Shibatomi, K., Iwasa, S.
    • Journal Title

      Journal of Science and Engineering 45,5A

      Pages: 37-42

    • Peer Reviewed
  • [Journal Article] Synthesis of a Novel Microporous Polymer-supported Ru(II) Catalyst and its Applications to Highly Efficient N-H Insertion Reactions2009

    • Author(s)
      Abu-Elftoh, A.-M., Phomkeona, K., Lorbriayao, B., Jingbaohom, N., Shibatomi, K., Iwasa, S.
    • Journal Title

      Journal of Science and Engineering 45,5A

      Pages: 118-123

    • Peer Reviewed
  • [Journal Article] Design and Synthesis a Novel Microporous Polymer-Supported Chiral Ru(II) Catalyst and its Applications to Highly Stereoselective Catalytic Asymmetric Cyclopropanations2009

    • Author(s)
      Abdel-Moneim Mohamed Abu-Elfotoh, Kesiny Phomkeona, Bounphak Lorbriayao, Ni-on Jingbaohom, Kazutaka Shibatomi, Seiji Iwasa
    • Journal Title

      Journal of Science and Technology 47

      Pages: 500-506

    • Peer Reviewed
  • [Journal Article] Chiral Bis(2-oxazolinyl)xanthene(xabox)/Transition Metal Complexes Catalyzed 1, 3-Dipolar Cycloaddition Reactions2008

    • Author(s)
      Phomkeona, K., Iwasa, S., Ishima, Y., Takemoto, T., Shibatomi, K., Nishiyama, H.
    • Journal Title

      Tetrahedron 64

      Pages: 1813-1822

    • Peer Reviewed
  • [Presentation] Asymmetric Inter-and Intramolecular Cyclopropanation Reactions Catalyzed by Reusable Macroporous Polymer-Supported Chiral Ru(II)-pheox Complex2010

    • Author(s)
      Abdel-Moneim Abu-Elfotoh, Kesiny Phomkeona, Kazutaka Shibatomi, Seiji Iwasa
    • Organizer
      The 11^<th> International Chemistry Conference and Exhibition in Africa (11 ICCA), The Role of Chemistry in Development of Africa
    • Place of Presentation
      Luxor, EGYPT.(Poster Presentation)
    • Year and Date
      20101120-20101123
  • [Presentation] Catalytic Asymmetric Carbene Transfer Reactions to Functionalized Alkenes : Highly Efficient Synthesis of Optically Active Cyclopropyl Amine and Ether Anologues2010

    • Author(s)
      Kesiny Phomkeona, Abdel-Moneim Abu-Elfotoh, Kazutaka Shibatomi, Seiji Iwasa
    • Organizer
      The 11^<th> International Chemistry Conference and Exhibition in Africa (11 ICCA), The Role of Chemistry in Development of Africa
    • Place of Presentation
      Luxor, EGYPT.(Oral Presentation)(依頼講演)
    • Year and Date
      20101120-20101123
  • [Presentation] Hydrogen Peroxide Oxidation of Phenol Derivatives Catalyzed by Microporous Polymer-Supported Ru(II)-dm-pheox2010

    • Author(s)
      Abdel-Moneim Mohamed Abu-Elfotoh, Nguyen Minh Ngoc, Kesiny Phomkeona, Kazutaka Shibatomi, Seiji Iwasa
    • Organizer
      The 2^<nd> Regional Conference on Global Environmental Issues for Sustainable Development in the ASEN Region
    • Place of Presentation
      Ho Chi Minh City,VIETNAM.(Oral Presentation)
    • Year and Date
      20100308-20100309
  • [Presentation] Creation, and breakthrough, Microporous Polymer-Supported Chiral Ru(II)-pheox Complex as an Efficient Catalyst for Enantioselective Cyclopropanation Reactions2009

    • Author(s)
      Abdel-Moneim Abu-Elfotoh, Kesiny Phomkeona, Kazutaka Shibatomi, Seiji Iwasa
    • Organizer
      Global COE in chemistry (Material Science Frontier Seminar), The most advanced science based on manufacturing technology : Molecular design
    • Place of Presentation
      Nagoya University, JAPAN.(Poster Presentation No.P-30)
    • Year and Date
      20091130-20091201
  • [Presentation] Design and Synthesis of a Novel Microporous Polymer-Supported Chiral Ru(II)-pheox Catalyst With High Reactivity, Enantioselectivity, Reusability and Storage Ability in Cyclopropanation Reactions2009

    • Author(s)
      A.M.Abu-Elfotoh, K.Phomkeona, K.Shibatomi, S.Iwasa
    • Organizer
      The Eleventh International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-11)
    • Place of Presentation
      Rihga Royal Hotel Kyoto, JAPAN.(Poster Presentation No.PC-053)
    • Year and Date
      20091109-20091113
  • [Presentation] Design and Synthesis a Novel Microporous Polymer-Supported Chiral Ru(II) Catalyst and its Applications to Highly Stereoselective Catalytic Asymmetric Cyclopropanations2009

    • Author(s)
      Abdel-Moneim Mohamed Abu-Elfotoh, Kesiny Phomkeona, Bounphak Lorbriayao, Ni-on Jingbaohom, Kazutaka Shibatomi, Seiji Iwasa
    • Organizer
      The 2^<nd> Regional Conference on Chemical Engineering : Chemical Engineering for Sustainable Development and Collaboration in the ASEAN Region
    • Place of Presentation
      Rex Hotel, Ho Chi Minh City, VIETNAM.(Oral Presentation O-1B)
    • Year and Date
      20091023-20091024
  • [Presentation] Synthesis a Novel Microporous Polymer-Supported Ru(II) Catalyst and its Applications to Highly Efficient N-H Insertion Reactions2009

    • Author(s)
      Abdel-Moneim Mohamed Abu-Elfotoh, Safumi Murakami, Kesiny Phomkeona, Bounphak Lorbriayao, Ni-on Jingbaohom, Kazutaka Shibatomi, Seiji Iwasa
    • Organizer
      The 2^<nd> Regional Conference on Chemical Engineering : Chemical Engineering for Sustainable Development and Collaboration in the ASEAN Region
    • Place of Presentation
      Rex Hotel, Ho Chi Minh City, VIETNAM.(Poster Presentation P-17)
    • Year and Date
      20091023-20091024
  • [Presentation] Microporous Polymer-supported Chiral Ru(II)pheox Catalysts and their Successful Application to Catalytic Asymmetric Cyclopropanation Reactions with High Reactivity, Enantioselectivity and Re-usability2009

    • Author(s)
      A.Abu-Elfotoh, K.Phomkeona, K.Shibatomi, S.Iwasa
    • Organizer
      The 1^<st> AUN/SEED-Net, Regional Conference on Materials 2009
    • Place of Presentation
      Equatorial Hotel Penang, MALAYSIA.(Oral Presentation)
    • Year and Date
      20090216-20090217
  • [Remarks] ホームページ等

  • [Patent(Industrial Property Rights)] アゾキシストロビン誘導体、アゾキシストロビンに対する抗体、またはそのフラグメントならびにそれらの抗体またはフラグメントを用いた測定キットおよび測定方法2010

    • Inventor(s)
      岩佐、三宅, その他
    • Industrial Property Rights Holder
      堀場製作所
    • Industrial Property Number
      特許,特願2010-149812
    • Filing Date
      20100000
  • [Patent(Industrial Property Rights)] アゾキシストロビン誘導体、アゾキシストロビンに対する抗体、またはそのフラグメントならびにそれらの抗体またはフラグメントを用いた測定キットおよび測定方法2010

    • Inventor(s)
      岩佐、三宅, その他
    • Industrial Property Rights Holder
      堀場製作所
    • Industrial Property Number
      特許,特願2010-149812
    • Acquisition Date
      20100000

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Published: 2012-01-26   Modified: 2016-04-21  

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