2010 Fiscal Year Final Research Report
Synthesis of Transmembrane Peptides Discriminate Multiple Biological activities from Heterodetic Dimeric Receptors
| Project/Area Number |
20550154
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Saga University |
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Principal Investigator |
HIROAKI Kodama Saga University, 工学系研究科, 教授 (80205418)
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| Co-Investigator(Kenkyū-buntansha) |
OSADA Satoshi 佐賀大学, 工学系研究科, 准教授 (50284609)
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| Project Period (FY) |
2008 – 2010
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| Keywords | シグナル伝達 / 生体分子 / 生理活性 / 活性酸素 / ダイマー |
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| Research Abstract |
Dimeric agonists and antagonists specific for the subtypes of human neutrophil receptors were synthesized by solid phase method. The activities of dimers exhibited cross-linker length dependences. Hetero-transmembrane peptides were alsoprepared and were showed priming activities for human neutrophils.
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[Journal Article] Apoptotic death of hematopoietic tumor cells through potentiated and sustained adhesion to fibronectin via VLA-42010
Author(s)
Y.Saito, T.Owaki, T.Matsunaga, M.Saze, S.Miura, M.Maeda, M.Eguchi, R.Tanaka, J.Taira, H.Kodama, S.Goto, Y.Niitsu, H.Terada, F.Fukai
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Journal Title
J. Biol. Chem. 285
Pages: 7006-7015
Peer Reviewed
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[Journal Article] VLA-5-mediated adhesion to fibronectin accelerates hemin-stimulated erythroid differentiation of K562 cells through induction of VLA-4 expression2009
Author(s)
R.Tanaka, T.Owaki, S.Kamiya, T.Matsunaga, H.Kodama, R.Hayashi, T.Abe, Y.P.Harada, M.Shimonaka, H.Yajima, H.Terada, F.Fukai
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Journal Title
J. Biol. Chem. 284
Pages: 19817-19825
Peer Reviewed
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