2010 Fiscal Year Final Research Report
Synthesis and evaluation of sugar derivatives for developing the antimicrobial agent against H. pylori
| Project/Area Number |
20550157
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | The Noguchi Institute |
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Principal Investigator |
YAMANOI Takashi The Noguchi Institute, 研究部, 主任研究員 (20182595)
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| Co-Investigator(Kenkyū-buntansha) |
FUJITA Masaya 公益財団法人野口研究所, 研究部, 研究員 (20321672)
ODA Yoshiki 公益財団法人野口研究所, 研究部, 研究員 (00442567)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 抗ピロリ / ピロリ菌 / αGlcNAc / ステロイド / N-アセチル-グルコサミン / グリコシド / クラスター / 医薬品 |
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| Research Abstract |
Aiming to develop the antimicrobial agent for H. pylori, a novel α-stereoselective glycosidation method of GlcNAc derivatives for producing the αGlcNAc glycosides has been successfully developed. This method was applicable to the productions of several kinds of αGlcNAc glycosides having a steroid structure, which led to the partial library construction of the αGlcNAc derivatives. In addition, the αGlcNAc assembly, which was expected to have a highly efficient antimicrobial activity toward H. pylori based on the sugar-cluster effect, was synthesized using cyclodextrin as a scaffolding molecule.
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[Journal Article] Glycoside hydrolase family 89 α-N-acetylglucosaminidase from clostridium perfringens specifically acts on GlcNAc 1,4Galβ1R at the non-reducing terminus of O-glycans in gastric mucin2011
Author(s)
M.Fujita, A.Tsuchida, A.Hirata, N.Kobayashi, K.Goto, K.Osumi, Y.Hirose, J.Nakayama, T.Yamanoi, H.Ashida, M.Mizuno
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Journal Title
The Journal of Biological Chemistry 286巻
Pages: 6479-6489
Peer Reviewed
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