2010 Fiscal Year Final Research Report
Focused Ultrasound Controlled Cavitation Bubble Collapse and Promotion of Sonoporation Effect
| Project/Area Number |
20560144
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fluid engineering
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| Research Institution | Hokkaido University of Education |
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Principal Investigator |
TOMITA Yukio Hokkaido University of Education, 教育学部, 教授 (00006199)
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| Co-Investigator(Renkei-kenkyūsha) |
KODAMA Tetsuya 東北大学, 医工学研究科, 教授 (40271986)
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| Project Period (FY) |
2008 – 2010
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| Keywords | キャビテーション / 超音波 / ソノポレーション / マイクロジェット / 衝撃波 |
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| Research Abstract |
The relation between Sonazoid destruction and the resultant cavitation phenomena has been investigated by employing ultrasound waves with the frequency of 1 MHz which were irradiated from two types of US probes with a flat boundary as well as a curved boundary. It was found that Sonazoid microbubbles were rapidly destroyed and the survival number was reduced to half the original number within 100 ms after ultrasound irradiation. The debris of microbubbles played a role of cavitation nuclei from which a large number of cavitation bubbles grew. A liquid micro-jet and a shock wave occurred during the short period of the bubble collapse. An impact pressure resulting from one of these short term phenomena seems to be an important cause of sonoporation which could make a fine hole in the cell membrane transiently.
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