2010 Fiscal Year Final Research Report
Oscillator network modeling of SCN neurons and its application to circadian rhythm
| Project/Area Number |
20560352
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Communication/Network engineering
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| Research Institution | Japan Advanced Institute of Science and Technology |
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Principal Investigator |
TOKUDA Isao Japan Advanced Institute of Science and Technology, 情報科学研究科, 准教授 (00261389)
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| Co-Investigator(Kenkyū-buntansha) |
UKUA Hirokazu 大阪府立大学, 生命環境科学研究科, 助教 (90405358)
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| Co-Investigator(Renkei-kenkyūsha) |
IKEGUCHI Tohru 埼玉大学, 大学院・理工学研究科, 教授 (30222863)
KORI Hiroshi お茶の水女子大学, お茶大アカデミックプロダクション, 特任助教 (80435974)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 概日リズム / 結合振動子 / 時系列解析 |
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| Research Abstract |
Towards comprehensive understanding of mammalian circadian rhythm, this project attempts to construct a mathematical model of neuronal network in the suprachiasmatic nucleus (SCN) using the recording data from physiological experiment. From the recording data of a rat SCN slice, network topology of the SCN neurons was estimated. The estimated network model was capable of reproducing the phase wave propagation, which is widely observed in the experiment. The phase wave is considered to play an important role for resolving the jet-lag problem. Next, as a preliminary experiment to control the circadian rhythm, delayed feedback technique was applied to a network of electrochemical oscillators to control the cluster states. Moreover, light pulse was injected to a plant leaf to desynchronize and resynchronize the plant circadian system.
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