2010 Fiscal Year Final Research Report
Development of Nano Device to Detect Cellular Stress by Using Supercritical Coating method.
| Project/Area Number |
20560707
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Properties in chemical engineering process/Transfer operation/Unit operation
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| Research Institution | Fukuoka University |
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Principal Investigator |
MISHIMA Kenji Fukuoka University, 工学部, 准教授 (40190623)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 薄膜・微粒子形成操作 / 医療工学 / 超臨界流体 |
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| Research Abstract |
In this work, we synthesized the peptides including an amino benzoic acid group as fluorescent probe in supercritical carbon dioxide in order to detect ACE inhibitor which reduces hypertension. The cellular stress detection was tried by using this synthesized fluorescent peptide. The effect of ACE inhibitor on the reduction of the cellular stress and blood vessel dilation was experimentally examined by means of cardiomyocyte. Furthermore, in order to search the hypertension control substances, separation and purification of target substances included in the soybean milk and the tofu (food related to the soybean) were carried out by using the synthesized fluorescent peptide.
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[Journal Article] Increment of Hypothalamic 2-Arachido-noylglycerol Induces the Preference for a High-fat Diet via Activation of Cannabinoid 1 Receptors2011
Author(s)
S.Higuchi, M.Ohji, M.Araki,R.Furuta, M.Katsuki, R.Yamaguchi, Y.Akitake, K.Matsuyama, K.Irie, K.Mishima, K.Mishima, K.Iwasaki, M.Fujiwara
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Journal Title
Behavioural Brain Research 216/1
Pages: 477-480
Peer Reviewed
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[Journal Article] Reducing Acyl Migration during Purification of 2-Arachidonoylglycerol from Biological Samples before Gas Chromatography Mass Spectrometry Analysis2010
Author(s)
S.Higuchi, K.Irie, T.Nakano, Y.Sakamoto, Y.Akitake, M.Araki, M.Ohji, R.Furuta, M.Katsuki, R.Yamaguchi, K.Matsuyama, K.Mishima, K.Mishima, K.Iwasaki, M.Fujiwara
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Journal Title
Analytical Sciences 26/11
Pages: 1199-1202
Peer Reviewed
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[Journal Article] Neuroprotective Effect of Repeated Treatment with Hericium erinaceum in Mice Subjected to Middle Cerebral Artery Occlusion2010
Author(s)
M.Hazekawa, A.Kataoka, K.Hayakawa, T.Uchimasu, R.Furuta, K.Irie, Y.Akitake, M.yoshida, T.Fujioka, N.Egashira, R.Oishi, K.Mishima, K.Mishima, T. Uchida, K. Iwasaki, M.Fujiwara
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Journal Title
J.Health Science 56(3)
Pages: 296-303
Peer Reviewed
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[Remarks] ホームページ等
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