2010 Fiscal Year Final Research Report
Study on the relationship between amino acid substitutions and natural selection taking into account the three dimensional structure of proteins
| Project/Area Number |
20570008
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
SUZUKI Yoshiyuki National Institute of Genetics, 大学院・システム自然科学研究科, 教授 (70353430)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 進化 / 蛋白質 / 立体構造 / アミノ酸置換 / 自然選択 |
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| Research Abstract |
A phylogenetic window analysis method was developed for detecting chronological changes in natural selection. CpG hypermutability was also taken into account for detecting natural selection. It was clarified that converting the alignment of amino acid sequences into that of codon sequences causes biased inference of natural selection. Influenza virus appeared to escape from host immune responses continuously in the tropical region. A method for detecting reassortment from a large number of genomic sequences was also developed.
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[Journal Article] Endogenous non-retroviral RNA virus elements in mammalian genomes.2010
Author(s)
Masayuki Horie, Tomoyuki Honda, Yoshiyuki Suzuki, Yuki Kobayashi, Takuji Daito, Tatsuo Oshida, Kazuyoshi Ikuta, Patric Jern, Takashi Gojobori, John M. Coffin, Keizo Tomonaga
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Journal Title
Peer Reviewed
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