2010 Fiscal Year Final Research Report
Hematopoietic tissue environment and molecular interactions in erythropoiesis
| Project/Area Number |
20570063
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Waseda University |
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Principal Investigator |
KATO Takashi Waseda University, 教育・総合科学学術院, 教授 (80350388)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 比較内分泌 |
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| Research Abstract |
In African clawed frog, Xenopus laevis, mammalian homologues of erythropoietin (EPO) and its receptor (EPO) express in the adult liver. Xenopus EPO had only 38% identity with mammalian EPO protein. By establishing a colony assay for the first time in amphibian, we were able not only to demonstrate the presence of erythroid progenitors in the liver capable of forming erythroid colonies but also the specific function of Xenopus EPO and the presence of EPO in anemic serum. Under conditions of hypothermic anemia, new erythrocytes were retained in the liver. This is the first study to describe the direct evidences in a physiological animal model to investigate the erythroid progenitor in amphibian hematopoietic tissues.
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Research Products
(28 results)
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[Journal Article] MicroRNA-500 as a potential diagnostic marker for hepatocellular carcinoma.2009
Author(s)
Yamamoto Y, Kosaka N, Tanaka M, Koizumi F, Kanai Y, Mizutani T, Murakami Y, Kuroda M, Miyajima A, Kato T, Ochiya T
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Journal Title
Biomarkers. 14(7)
Pages: 529-538
Peer Reviewed
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[Presentation] Characterization of Xenopus laevis thrombocytic cells stimulated by thrombopoietin in liquid culture.2010
Author(s)
Tahara A, Tanizaki Y, Okui T, Meguro M, Kinoshita S, Maekawa S, Yamauchi M, Obuchi-Shimoji M, Ishida-Iwata T, Nagai Y, Kuroki R, Kato T.
Organizer
39th Annual Scientific Meeting of ISEH-Society for Hematology and Stem Cells.(Abstruct 109, Poster 084)
Place of Presentation
Melbourne, Australia
Year and Date
20100915-20100918
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[Presentation] Lipopolysaccharide administration in adult African clawed frog as an animal model for leukocytosis.2010
Author(s)
Onda N, Onodera H, Kato T, Ishida K, Mano Y, Nagasawa K, Akatsuka R, Maeno M, Kato T.
Organizer
39th Annual Scientific Meeting of ISEH-Society for Hematology and Stem Cells.(Abstruct 142, Poster 088)
Place of Presentation
Melbourne, Australia
Year and Date
20100915-20100918
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[Presentation] Proliferation and Differentiation of Thrombocyte Progenitors In the Liver and the Spleen In Xenopus Laevis Under the Stimulation of Thrombopoietin. Poster Board I-992, Abstract 20122010
Author(s)
Tanizaki Y, Tahara A, Kinoshita S, Yamauchi M, Mizue M, Nagasawa K, Ishida-Iwata T, Obuchi-Shimoji M, Nogawa-Kosaka N, Kato T.
Organizer
52nd Annual Meeting of the American Society of Hematology
Place of Presentation
Orlando, Florida, USA.
Year and Date
2010-12-04
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[Presentation] トロンボポエチン様分子の刺激に応答するアフリカツメガエル栓球前駆細胞の性質2010
Author(s)
谷崎祐太,田原彩香,目黒瑞枝,永澤和道,山内志毅,木下紗也香,前川峻,石田(岩田)貴子,小渕(下地)美弥子,加藤尚志
Organizer
第72回日本血液学会学術集会(OS-1-53,「血小板産生・活性化」)
Place of Presentation
横浜パシフィコ(一般口演)
Year and Date
2010-09-24
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[Presentation] Chronic anemia induced by low-temperature is caused by impaired erythrocyte traffic from liver to peripherai vesicles in African crowed frog, Xenopus laevis.2008
Author(s)
Maekawa S, Kuramochi Y, Iemura H, Nogawa-Kosaka N, Nishikawa H, Aizawa Y, Kato T.
Organizer
37th Annual Scientific Meetingm, International Society for Hematology and Stem Cells.(Abstract No. 078)
Place of Presentation
Boston, Massachusetts, USA(The Top Five Posters Award)
Year and Date
2008-07-09
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