2010 Fiscal Year Final Research Report
Elucidation of the visual cycle in the insect retina
| Project/Area Number |
20570069
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Shimane University |
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Principal Investigator |
OZAKI Koichi Shimane University, 生物資源科学部, 教授 (90194539)
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| Co-Investigator(Renkei-kenkyūsha) |
SATOH Akiko 名古屋大学, 大学院・理学研究科, 准教授 (30529037)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 視物質 / 視物質回路 / 昆虫 / レチノイド / 異性化 / 網膜 / 視細胞 / コオロギ |
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| Research Abstract |
The metabolic pathway of visual chromophore in the insect retina has been investigated with particular focus on the following subjects, (1) identification of the protein that isomerizes all-trans retinoid to 11-cis form by light, and (2) metabolic pathway of the chromophore in the hemimetabolous insect. Researches in this project have elucidated that PDH, previously identified as a retina-specific oxidoreductase, is a strong candidate for a retinoid photoisomerase. In addition, HPLC-analyses of retinoid compositions in the light- and dark-adapted retinas of crickets uncovered their visual cycle and a novel protein involved in the cycle.
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