Investigation of a tachykininergic proteases-associated oocyte growth

2010 Fiscal Year Final Research Report

• Project/Area Number: 20570077
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Animal physiology/Animal behavior
• Research Institution: Suntory Institute for Bioorganic Research
• Principal Investigator: SATAKE Honoo Suntory Institute for Bioorganic Research, 分子生物学研究部, 主幹研究員 (20280688)
• Project Period (FY): 2008 – 2010
• Keywords: タキキニン / カタユウレイボヤ / 卵細胞 / プロテアーゼ / 哺乳類 / 成長機構 / 卵巣

Research Abstract

We have substantiated that a neuropeptide, tachykinin, up-regulates growth of vitellogenic oocytes via the activation of proteases such as cathepsin D, carboxypeptidase, and chymotrypsin. Mooreover, this novel oocyte growth pathway has been shown to be suppressed by another neuropeptide, neurotensin. We have also revealed that the protease-associated oocyte growth is essentially conserved in mice.

Research Products

• [Journal Article] Peptidomic analysis of the central nervous system of the protochordate, Ciona intestinalis : homologs and prototypes of vertebrate peptides and novel peptides (2011)
  • Author(s): Kawada T., Ogasawara M., Sekiguchi T., Aoyama M., Hotta K., Oka K, Satake H.
  • Journal Title: Endocrinology 152(6) Pages: 2416-2427
  • Peer Reviewed
• [Journal Article] Expression of neuropeptide- and hormone-encoding genes in the Ciona intestinalis larval brain (2011)
  • Author(s): Hamada M., Shimozono N., Ohta N., Satou Y., Horie T., Kawada T., Satake H., Sasakura Y., Satoh N.
  • Journal Title: Dev. Biol. 352(2) Pages: 202-214
  • Peer Reviewed
• [Journal Article] Bombyx orcokinins are brain-gut peptides involved in the neuronal regulation of ecdysteroidogenesis (2011)
  • Author(s): Yamanaka N., Roller L., Zitnan D., Satake H., Mizoguchi A., Kataoka H., Tanaka Y.
  • Journal Title: J.Comp.Neurol. 519(2) Pages: 238-246
  • Peer Reviewed
• [Journal Article] Functional diversity of signaling pathways through G protein-coupled receptor heterodimerization with a species-specific orphan receptor subtype (2010)
  • Author(s): Sakai T., Aoyama M., Kusakabe T., Tsuda M., Satake H.
  • Journal Title: Mol.Biol.Evol. 27(5) Pages: 1097-1106
  • Peer Reviewed
• [Journal Article] Efficient transposition of a single Minos transposon copy in the genome of the ascidian Ciona intestinalis with a transgenic line expressing transposase in eggs (2010)
  • Author(s): Hozumi A., Kawai N., Yoshida R., Ogura Y., Ohta N., Satake H., Satoh N., Sasakura Y.
  • Journal Title: Dev.Dyn. 239(4) Pages: 1076-1088
  • Peer Reviewed
• [Journal Article] Ecdysis triggering hormone signaling in arthropods (2010)
  • Author(s): Roller L., Zitnanova I, Dai L, Simo L., Park Y., Satake H., Tanaka Y., Adams M.E., Zitnan D.
  • Journal Title: Peptides 31(3) Pages: 429-441
  • Peer Reviewed
• [Journal Article] Comparative view on Toll-like receptors of lower animals (2010)
  • Author(s): Satake H., Sasaki N.
  • Journal Title: Zool.Sci. 27(2) Pages: 154-161
  • Peer Reviewed
• [Journal Article] Neuropeptides, hormone peptides, and their receptors in Ciona intestinalis : an update (2010)
  • Author(s): Kawada T., Sekiguchi T., Sakai T., Aoyama M., Satake H.
  • Journal Title: Zool.Sci. 27(2) Pages: 134-153
  • Peer Reviewed
• [Journal Article] A novel inhibitory gonadotropin- releasing hormone-related neuropeptide in the ascidian, Ciona intestinalis (2009)
  • Author(s): Kawada T., Aoyama M., Okada I., Sakai T., Sekiguchi T., Ogasawara M., Satake H.
  • Journal Title: Peptides 30(12) Pages: 2200-2205
  • Peer Reviewed
• [Journal Article] Toll-like receptors of the ascidian, Ciona intestinalis : prototypes with hybrid functionalities of vertebrate Toll-like receptors (2009)
  • Author(s): Sasaki N., Ogasawara M., Sekiguchi T., Kusumoto S., Satake H.
  • Journal Title: J.Biol.Chem. 284(40) Pages: 27336-27343
  • Peer Reviewed
• [Journal Article] Calcitonin in a protochordate, Ciona intestinalis : the prototype of the vertebrate Calcitonin/Calcitonin gene related peptide family (2009)
  • Author(s): Sekiguchi T., Suzuki N., Fujiwara N., Aoyama M., Kawada M., Sugase K., Murata Y., Sasayama Y., Ogasawara M., Satake H.
  • Journal Title: FEBS J. 276(16) Pages: 4437-4447
  • Peer Reviewed
• [Journal Article] An ecdysteroid-inducible IGF-like peptide regulates adult development of the silkmoth Bombyx mori (2009)
  • Author(s): Okamoto N., Yamanaka N., Satake H., Saegusa H., Kataoka H. Mizoguchi A.
  • Journal Title: FEBS J. 276(5) Pages: 1221-1232
  • Peer Reviewed
• [Journal Article] Characterization of a novel vasopressin/oxytocin superfamily peptide and its receptor from an ascidian, Ciona intestinalis (2008)
  • Author(s): Kawada T., Sekiguchi T., Itoh Y., Ogasawara M., Satake H.
  • Journal Title: Peptides 29(10) Pages: 1672-1678
  • Peer Reviewed
• [Journal Article] A novel biological role of tachykinins as an upregulator of oocyte growth : identification of an evolutionary origin of tachykinergic functions in the ovary of the ascidian, Ciona intestinalis (2008)
  • Author(s): Aoyama M., Kawada T., Fujie M., Hotta K., Sakai T., Sekiguchi T., Oka K., Satoh N., Satake H.
  • Journal Title: Endocrinology 149(9) Pages: 4346-4356
  • Peer Reviewed
• [Journal Article] Recent advances and perceptions in studies of heterodimerization between G protein-coupled receptors (2008)
  • Author(s): Satake H., Sakai T.
  • Journal Title: Protein Pept.Lett. 15(3) Pages: 300-308
  • Peer Reviewed
• [Presentation] ホヤGnRH受容体ヘテロダイマー形成によるシグナル伝達調節の多様性 (2010)
  • Author(s): 酒井、青山、日下部、津田、佐竹
  • Organizer: 日本動物学会第81回大会
  • Place of Presentation: 東京
  • Year and Date: 2010-09-23
• [Presentation] 卵巣においてタキキニンによって制御されるカテプシンDの局在 (2010)
  • Author(s): 青山、川田、佐竹
  • Organizer: 日本動物学会第81回大会
  • Place of Presentation: 東京
  • Year and Date: 2010-09-23
• [Presentation] タキキニンファミリーに見られる分子と機能の進化 (2009)
  • Author(s): 佐竹、青山、川田、関口、酒井、伊丹、安田
  • Organizer: 第35回日本比較内分泌学会大会
  • Place of Presentation: 静岡
  • Year and Date: 2009-11-18
• [Presentation] 哺乳類卵巣組織におけるタキキニンの生物学的役割について (2009)
  • Author(s): 青山、川田、佐竹
  • Organizer: 第34回日本比較内分泌学会大会・日本比較生理生化学会第31回大会合同大会
  • Place of Presentation: 大阪
  • Year and Date: 2009-10-22
• [Presentation] カタユウレイボヤ脳神経節に実在するペプチドの神経ペプチドの網羅的解析 (2009)
  • Author(s): 川田、伊藤、佐竹
  • Organizer: 第34回日本比較内分泌学会大会・日本比較生理生化学会第31回大会合同大会
  • Place of Presentation: 大阪
  • Year and Date: 2009-10-22
• [Presentation] 哺乳類卵巣組織におけるタキキニンの生物学的役割について (2009)
  • Author(s): 青山、川田、佐竹
  • Organizer: 日本動物学会第80回年会
  • Place of Presentation: 静岡
  • Year and Date: 2009-09-19
• [Presentation] カタユウレイボヤのニューロテンシン様ペプチドの機能解析 (2009)
  • Author(s): 川田、青山、関口、小笠原、濱田、佐藤、佐竹
  • Organizer: 日本動物学会第80回年会
  • Place of Presentation: 静岡
  • Year and Date: 2009-09-19
• [Book] Invertebrate immunity(Kenneth Soderhall ed.)(Urochordate immunity)(Austin, TX) (2010)
  • Author(s): Nonaka M., Satake H.
  • Total Pages: 302-310
  • Publisher: Landes Bioscience.
• [Book] Evolutionary aspects of molecular forms and biological functions of oxytocin family peptides in Handbook of Oxytocin Research : Synthesis, Storage and Release, Actions, and Drug Forms(Jastrow H. and Feuerbach D. eds.)(Hauppauge, NY) (2009)
  • Author(s): Kawada T., Sekiguchi T., Sugase K., Satake H.
  • Total Pages: 59-85
  • Publisher: Nova Science Publishers, Inc.
• [Remarks] ホームページ等
  • URL: www.sunbor.or.jp