2010 Fiscal Year Final Research Report
Mechanism and evolution of developmental robustness against perturbation of the BICOID morphogen in Drosophila embryo
| Project/Area Number |
20570100
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biodiversity/Systematics
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
TAKANO Toshiyuki National Institute of Genetics, 集団遺伝研究系, 准教授 (90202150)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 進化 / 発生・分化 / 頑健性 / モルフォジェン / bicoid |
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| Research Abstract |
The maternal effect gene bicoid (bcd) serves as a morphogen and establishes AP axis in Drosophila. Whereas increased dosage of bcd causes enlargement of prospective head region in early embryogenesis, the adults have normal head size. Excessive cell death contributes to reduce the expanded head region; however, nothing is known about what triggers cell death and what kinds of genes are involved in the repair. From genetic screening and microarray experiments, we identified a candidate gene responsible for the repair, which is also involved in the response to irradiation-induced DNA damage.
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