2010 Fiscal Year Final Research Report
Interaction between BDNF and polysialic acid localized in brains
| Project/Area Number |
20570107
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
SATO Chihiro Nagoya University, 生物機能開発利用研究センター, 准教授 (10343211)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ポリシアル酸 / 神経科学 / シアル酸 / 脳・神経 / 糖鎖 |
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| Research Abstract |
Polysialic acid (polySia) is the anionic polysaccharide expressed mainly in vertebrate brains. PolySia modifies embryonic NCAM and functions as a negative regulator between cell-cell/extracellular matrix via its bulky and exclusive features. In this study, we demonstrated that polySia directly binds to a brain derived neurotrophic factor (BDNF) and that through its interaction it regulates the ligand-receptor interactions.
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[Journal Article] Developmental stage-dependent expression of an α2,8-trisialic acid unit on glycoproteins in mouse brain.2010
Author(s)
Inoko, E., Nishiura, Y., Tanaka, H., Takahashi, T., Furukawa, K., Kitajima, K., Sato, C.
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Journal Title
Glycobiology 20
Pages: 916-928
Peer Reviewed
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[Journal Article] Survival signals of hepatic stellate cells in liver regeneration are regulated by glycosylation changes in rat vitronectin, especially decreased sialylation.2010
Author(s)
Sano K, Miyamoto Y, Kawasaki N, Hashii N, Itoh S, Murase M, Date K, Yokoyama M, Sato, C., Kitajima K, Ogawa H.
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Journal Title
J Biol Chem. 285
Pages: 17301-17309
Peer Reviewed
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[Journal Article] Membrane microdomains from early gastrula embryos of medaka, Oryzias latipes are a plat form of E-cadherin and carbohydrate-mediated cell-cell interactions during epiboly.2009
Author(s)
Adachi T., Sato, C., Kishi, Y., Totani, K., Murata, T., Usui, T., Kitajima, K.
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Journal Title
Glycoconjugate J. 26
Pages: 285-299
Peer Reviewed
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[Book] Glycoscience Lab Manual (Taniguchi N, Suzuki A, Ito Y, Narimatsu H, Kawasaki T, Hase S, eds)(Structural analysis of polysialic acid.)2008
Author(s)
Sato, C., Kitajima, K.
Total Pages
77-81
Publisher
Springer, Japan
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[Book] in Glycoscience Lab Manual (Taniguchi N, Suzuki A, Ito Y, Narimatsu H, Kawasaki T, Hase S, eds)(Membrane microdomain as a platform of carbohydrate-mediated interaction during early development of medaka fish)2008
Author(s)
Adachi, T., Sato, C., Kitajima, K.
Total Pages
299-302
Publisher
Springer, Japan
