2010 Fiscal Year Final Research Report
Protein C-mannosylation and signaling related to innate immunity
| Project/Area Number |
20570112
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
IHARA Yoshito Wakayama Medical University, 医学部, 教授 (70263241)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRAISHI Noriyuki 和歌山県立医科大学, 医学部, 准教授 (30133169)
INAI Yoko 和歌山県立医科大学, 医学部, 助教 (20316087)
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| Co-Investigator(Renkei-kenkyūsha) |
MANABE Shino 理化学研究所, 基幹研究所, 専任研究員 (60300901)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 糖質 |
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| Research Abstract |
C-Mannosylated peptides derived from the thrombospondin type 1 repeat (TSR) are involved in the regulation of innate immunity. In this study, we searched for the proteins that bind to C-mannosylated TSR-derived peptides in macrophage-like RAW264.7 cells, and identified heat shock cognate protein 70 (Hsc70). C-Mannosylated peptides enhanced the Hsc70-induced signaling to produce TNF-α, demonstrating a novel function of C-mannosylation of TSR-derived peptides in terms of interaction with Hsc70 to regulate cellular signaling.
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