2010 Fiscal Year Final Research Report
Analysis of the metabolic syndrome using a carbohydrate chain deficient mice.
| Project/Area Number |
20570122
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
YAMASHITA Tadashi Hokkaido University, 大学院・先端生命科学研究院, 准教授 (30220338)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 糖鎖 / 糖脂質 / ノックアウトマウス |
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| Research Abstract |
A remarkable difference was observed in the liver pathology as a result of giving the calorie-rich food that caused the metabolic syndrome by using GM3 synthesis enzyme (GM3S) deficient mouse. As for a reaction of an immunity system cell, the increase of IL-6 was observed. Moreover, an increase in the amount of the cytokine under the LPS stimulation was observed in mouse embryo fibroblast (MEF) derived from GM3 knockout mouse. As for central nerve system, GM3 knockout mice showed the loss of function by behavior test. An amount of glycoprotein increased in the GM3 knockout mice.
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[Journal Article] Threshold in stage-specific embryonic glycotypes uncovered by a full portrait of dynamic N-gylcan expresion during cell differentiation.2010
Author(s)
Amano M, Yamaguchi M, Takegawa Y, Yamashita T, Terashima M, Furukawa J, Miura Y, Shinohara Y, Iwasaki N, Minami A, Nishimura S.
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Journal Title
Mol Cell Proteomics. 9
Pages: 523-537
Peer Reviewed
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