2010 Fiscal Year Final Research Report
Control of Gene-specific Expression by the Inducible Transcription Regulator IκB-ζ
| Project/Area Number |
20570134
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
YAMAZAKI Soh Kyushu University, 医学研究院, 講師 (70315084)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 遺伝子発現 / 転写 / クロマチン / 自然免疫 / 炎症 |
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| Research Abstract |
We previously identified the new protein IκB-ζ, which binds to NF-κB in the nucleus. IκB-ζ is essential for expression of a group of NF-κB-regulated genes. In the present study, we attempted to elucidate mode of action for IκB-ζ in transcriptional up-regulation of target genes using the knockout cells and the cells in which IκB-ζ expression can be artificially induced by zinc. We revealed that IκB-ζ is necessary for association of NF-κB with the target promoters.
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