2010 Fiscal Year Final Research Report
Studies on orphan G protein-coupled receptors which are related to body size : ligand search and their functions
| Project/Area Number |
20570140
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
MITOMA Junya Tohoku Pharmaceutical University, 薬学部, 講師 (10281627)
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| Project Period (FY) |
2008 – 2010
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| Keywords | シグナル伝達 / 糖 / 糖尿病 / GPCR / リガンド |
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| Research Abstract |
We found that the mice deficient in G protein-coupled receptor Rigp2 (Rigp2-/-) are significantly smaller than wild-type mice. Because the number of Rigp2-/- mice born from heterozygote mating is much smaller than that of Rigp2+/- and +/+ mice, there may be some defect during development. We also found that the only one of Asp residues of this protein has N-linked glycans. We could not identify a ligand for this GPCR.
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[Journal Article] The N-glycolyl form of mouse sialyl Lewis X is recognized by selectins but not by HECA-452 and FH6 antibodies that were raised against human cells.2009
Author(s)
Mitoma, J., Miyazaki, T., Sutton-Smith, M., Suzuki, M., Saito, H., Yeh, J. C., Kawano, T., Hindsgaul, O., Seeberger, P.H., Panico, M., Haslam, S.M., Morris, H.R., Cummings, R.D., Dell, A., Fukuda, M.
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Journal Title
Glycoconj.J. 26(5)
Pages: 511
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