2010 Fiscal Year Final Research Report
The Physiological function of V-ATPase involved in membrane traffick
| Project/Area Number |
20570142
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Doshisha Women's College of Liberal Arts |
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Principal Investigator |
WADA Ge-Hong (孫 戈虹) Doshisha Women's College of Liberal Arts, 薬学部, 教授 (00314427)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 膜輸送と輸送タンパク質 / プロトンポンプ |
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| Research Abstract |
Acidification inside membrane compartments is a common feature of all eukaryotic cells. The acidic milieu, generated by the V-ATPase, is involved in many physiological processes including secretion, protein processing, and others. Using subunit-specific knockout mice, we have shown that the function of V-ATPase is involved in insulin secretion, born resorption and macrophage functions. We have also revealed that the (pro)renin receptor functions as an assembly factor of the V-ATPase complex.
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Research Products
(14 results)
