2010 Fiscal Year Final Research Report
Functional compensation and independency of two sphingomyelin synthases
| Project/Area Number |
20570145
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | National Institute for Longevity Sciences,NCGG |
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Principal Investigator |
WATANABE Ken National Institute for Longevity Sciences,NCGG, 運動器疾患研究部, 室長 (10342966)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 酵素 / 脂質 / 動物 |
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| Research Abstract |
Two sphingomyelin synthase, SMS1 and SMS2, are structurally homologous proteins but exhibit different cellular localization. In this study, mice deficient either for Sms1 or Sms2 gene were generated. Through the phenotypic analyses of Sms1KO and Sms2KO mice, the enzymes partially compensate in sphingomyelin biosynthesis but play different roles in biological aspects and physiology.
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[Journal Article] Mitochondrial Dysfunction and Increased Reactive Oxygen Species Impair Insulin Secretion in Sphingomyelin Synthase 1 Null Mice.2011
Author(s)
Yano M, Watanabe K, Yamamoto T, Ikeda K, Senokuchi T, Lu M, Kadomatsu T, Tsukano H, Ikawa M, Okabe M, Yamaoka S, Okazaki T, Umehara H, Gotoh T, Song WJ, Node K, Taguchi R, Yamagata K, Oike Y.
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Journal Title
J.Biol.Chem. 286
Pages: 3992-4002
Peer Reviewed
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[Journal Article] Dynamic modification of sphingomyelin in lipid microdomains controls development of obesity, fatty liver, and type 2 diabetes.
Author(s)
Mitsutake S, Zama K, Yokota H, Yoshida T, Tanaka M, Mitsui M, Ikawa M, Okabe M, Tanaka Y, Yamashita T, Takemoto H, Okazaki T, Watanabe K, Igarashi Y.
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Journal Title
J.Biol.Chem. 286(in press)
Pages: 2011
Peer Reviewed
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