2010 Fiscal Year Final Research Report
Actin filaments function as a tension sensor via tension dependent binding of cofilin to the filament
| Project/Area Number |
20570151
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | Nagoya University |
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Principal Investigator |
TATSUMI Hitoshi Nagoya University, 医学系研究科, 准教授 (20171720)
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| Co-Investigator(Kenkyū-buntansha) |
SOKABE Masahiro 名古屋大学, 大学院・医学系研究科, 教授 (10093428)
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| Project Period (FY) |
2008 – 2010
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| Keywords | コフィリン / アクチン / 一分子測定 / ねじれ / 光ピンセット |
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| Research Abstract |
When forces were applied to the filament, it was severed after the application of cofilin with a significantly larger delay in comparison with the control filaments suspended in solution. The binding rate of cofilin to an actin bundle was decreased when the bundle was tensed. These results demonstrate that tension in the actin filament prevents the binding of cofilin, resulting in a decrease in the effective severing activity of cofilin.
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[Journal Article] Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus.2009
Author(s)
Enomoto A, Asai N, Namba T, Wang Y, Kato T, Tanaka M, Tatsumi H, Taya S, Tsuboi D, Kuroda K, Kaneko N, Sawamoto K, Miyamoto R, Jijiwa M, Murakumo Y, Sokabe M, Seki T, Kaibuchi K, Takahashi M.
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Journal Title
Peer Reviewed
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