2010 Fiscal Year Final Research Report
Molecular mechanism of Kid-mediated anaphase chromosome compaction
| Project/Area Number |
20570161
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OHSUG Miho The University of Tokyo, 医科学研究所, 准教授 (00332586)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 染色体分配 / 核形成 / キネシンファミリー分子 |
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| Research Abstract |
The chromokinesin Kid/kinesin-10 is a multifunctional mitotic motor protein. Kid mediates tight clustering of anaphase chromosomes, which is important for the formation of daughter nuclei that enclosed entire set of segregated chromosomes. In this study, we showed that DNA-binding activity is essential and motor and oligomerization activities are important for the Kid-mediated anaphase chromosome compaction.
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