2010 Fiscal Year Final Research Report
Analysis of molecular mechanisms of endocytosis in C.elegans development
| Project/Area Number |
20570176
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Gunma University |
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Principal Investigator |
SATO Ken Gunma University, 生体調節研究所, 教授 (30311343)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 線虫 / エンドサイトーシス / 低分子量GTPase |
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| Research Abstract |
We analyzed the rme mutants which show defects in yolk uptake by oocytes in C.elegans and identified novel rme genes conserved from the worm to human. We found that the rme-3 gene encodes clathrin. We also revealed that RME-4 functions on coated pits and/or vesicles to recruit small GTPase RAB-35, which in turn functions in the endosomes to promote receptor recycling. We further identified a candidate for the Rab35 effector molecule and examined its functions in endocytosis.
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