2010 Fiscal Year Final Research Report
Analysis of the potential roles of Nucleoporin in oncogenesis
| Project/Area Number |
20570184
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Osaka University |
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Principal Investigator |
OKA Masahiro Osaka University, 大学院・生命機能研究科, 助教 (40432504)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ヌクレオポリン / 核外輸送 / Nup98 / Crm1 |
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| Research Abstract |
Nup98 is a frequent target of chromosomal rearrangements in leukemia, which is associated with the disease development. Our study revealed that Nup98 binds to Crm1, a nuclear export factor, and is involved in protein export from the nucleus to the cytoplasm. In addition, we demonstrated that the expression of Nup98-HoxA9 fusion inhibits the nuclear export.
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