Analysis of mitochondrial proteins required for regulation of mitochondrial morphology

2010 Fiscal Year Final Research Report

• Project/Area Number: 20570185
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cell biology
• Research Institution: Kyushu University
• Principal Investigator: OKA Toshihiko Kyushu University, 医学研究院, 准教授 (40263321)
• Project Period (FY): 2008 – 2010
• Keywords: ミトコンドリア / 形態形成 / MICS1 / KLP6

Research Abstract

To identify genes for regulation of mitochondrial morphology, we applied a feeding RNA interference in nematode C. elegans, and searched genes for mitochondrial proteins and molecular motors. We showed that MICS1 and KLP6 are required for mitochondrial morphology and transport, respectively.

Research Products

• [Journal Article] KLP6, a new kinesin regulating morphology and transport of mitochondria in neuronal cells. (2011)
  • Author(s): Tanaka, K., Sugiura, Y., Ichishita, R., Mihara, K., Oka, T.
  • Journal Title: J. Cell Sci. in press
  • Peer Reviewed
• [Journal Article] Identification of a novel protein MICS1 that is involved in maintenance of mitochondrial morphology and apoptotic release of cytochrome c. (2008)
  • Author(s): Oka, T., Sayano, T., Tamai, S., Yokota, S., Kato, H., Fujii, G., Mihara, K.
  • Journal Title: Mol. Biol. Cell 19 Pages: 2597-2608
  • Peer Reviewed
• [Journal Article] An RNAi screen for mitochondrial proteins required to maintain the morphology of the organelle in C. elegans. (2008)
  • Author(s): Ichishita, R., Tanaka, K., Sugiura, Y., Sayano, T., Mihara, K., Oka, T.
  • Journal Title: J. Biochem. 143 Pages: 449-454
  • Peer Reviewed
• [Presentation] 日本生化学会・日本分子生物学会合同大会 (2010)
  • Organizer: 神戸ポートアイランド「ミトコンドリアの形態形成と軸索移動に関わる新規キネシンの機能解析」
  • Year and Date: 2010-12-09
• [Presentation] American Society of Cell Biology (2009)
  • Organizer: 米国サンディエゴコンベンションセンター「MICS1 is involved in maintenance of mitochondrial morphology and apoptotic release of cytochrome c」
  • Year and Date: 2009-12-06
• [Presentation] 日本蛋白質科学会 (2009)
  • Organizer: 熊本全日空ホテルニュースカイ「ミトコンドリアAAA蛋白質とその生理機能」
  • Year and Date: 2009-05-20
• [Presentation] 日本生化学会・日本分子生物学会合同大会 (2008)
  • Organizer: 神戸ポートアイランド「Regulation of mitochondrial morphology and cristae organization」
  • Year and Date: 2008-12-09
• [Presentation] 日本細胞生物学会 (2008)
  • Organizer: パシフィコ横浜「新規ミトコンドリアタンパク質MICS1の機能解析」
  • Year and Date: 2008-06-29
• [Book] 細胞工学(「ミトコンドリア膜構造変化とアポトーシス制御」) (2010)
  • Author(s): 大寺秀典、岡敏彦
  • Total Pages: 438-442