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2010 Fiscal Year Final Research Report

Study on the molecular mechanisms by which general cell polarity-regulating kinase, PAR-1, regulates epithelial polarity

Research Project

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Project/Area Number 20570186
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cell biology
Research InstitutionYokohama City University

Principal Investigator

SUZUKI Atsushi  Yokohama City University, 医学研究科, 准教授 (00264606)

Project Period (FY) 2008 – 2010
Keywords細胞極性 / PAR / 上皮細胞 / 微小管
Research Abstract

Epithelial cells cover the boundary between our body and external environment, and thus develop functional asymmetry (polarity) between the cell membranes facing internal and external environment. It has been demonstrated that abnormal epithelial polarity leads to physiological deficiency. In this study, we have analyzed how the general cell polarity-regulating protein, PAR-1, plays important roles for epithelial polarity, especially by analyzing its binding proteins.

  • Research Products

    (23 results)

All 2011 2010 2009 2008 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (13 results) Remarks (1 results)

  • [Journal Article] KIBRA suppresses apical exocytosis through inhibition of aPKC kinase activity in epithelial cells.2011

    • Author(s)
      Yoshihama Y, Sasaki K, Horikoshi Y, Suzuki A, Ohtsuka T, Hakuno F, Takahashi S, Ohno S, Chida K.
    • Journal Title

      Curr Biol 21

      Pages: 705-711

    • Peer Reviewed
  • [Journal Article] Proliferation of human lung cancer in an orthotopic transplantation mouse model.2010

    • Author(s)
      Kan Y, Ohmura M, Suzuki A, Theeraladanon C, Oka T, Nakagami Y, Suzuki A, Nagashima Y, Inoue T.
    • Journal Title

      Exp. Therapeu. Med. 1

      Pages: 471-475

    • Peer Reviewed
  • [Journal Article] The 8th and 9th tandem spectrin-like repeat of utrophin cooperatively form a functional unit to interact with polarity-regulating kinase Par-1b.2010

    • Author(s)
      Yamashita K, Suzuki A, Satoh Y. Ide M, Amano Y, Masuda-Hirata M, Hayashi Y, Hamada K, Ogata K, Ohno S.
    • Journal Title

      BBRC 391

      Pages: 812-817

    • Peer Reviewed
  • [Journal Article] An essential role of the aPKC-Aurora A-NDEL1 pathway on neurite elongation by modulation of microtubule dynamics.2009

    • Author(s)
      Mori D, Yamada M, Mimori-Kiyosue Y, Shirai Y, Suzuki A, Ohno S, Saya H, Wynshaw-Boris A, Hirotsune S.
    • Journal Title

      Nat. Cell Biol. 11(9)

      Pages: 1057-1068

    • Peer Reviewed
  • [Journal Article] Intracellular polarity protein PAR-1 regulates extracellular laminin assembly by regulating the dystroglycan complex.2009

    • Author(s)
      Masuda-Hirata. M, Suzuki A, Amano Y, Yamashita K, Ide M, Yamanaka T, Sakai M, Imamura M, Ohno S.
    • Journal Title

      Genes to Cells 14

      Pages: 835-850

    • Peer Reviewed
  • [Journal Article] Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells.2009

    • Author(s)
      Horikoshi Y, Suzuki A, Yamanaka T, Sasaki K, Mizuno K, Sawada H, Yonemura S, Ohno S.
    • Journal Title

      J. Cell Sci. 122

      Pages: 1595-1606

    • Peer Reviewed
  • [Journal Article] Affixin activates Rac1 via bPix in C2C12 myoblast.2008

    • Author(s)
      Matsuda C, Kameyama K, Suzuki A, Mishima W, Yamaji S, Okamoto H, Nishino I, Hayashi Y.
    • Journal Title

      FEBS Lett 582

      Pages: 1189-1196

    • Peer Reviewed
  • [Journal Article] Regulation of epithelial and endothelial junctions by PAR proteins.2008

    • Author(s)
      Ebnet K, Iden S, Gerke V, Suzuki A.
    • Journal Title

      Front Biosci 13

      Pages: 6520-6536

    • Peer Reviewed
  • [Journal Article] aPKC enables development of zonula adherens by antagonizing centripetal contraction of the circumferential actomyosin cables.2008

    • Author(s)
      Kishikawa M, Suzuki A, Ohno S.
    • Journal Title

      J Cell Sci 121

      Pages: 2481-2492

    • Peer Reviewed
  • [Presentation] KIBRA suppresses apical exocytosis through inhibition of aPKC kinase activity in epithelial cells.2010

    • Author(s)
      Yoshihama Y, Sasaki K, Horokoshi Y, Ohtsuka T, Hakuno F, Takahashi S-I, Suzuki A, Ohno S, Chida K
    • Organizer
      The 50th American Society for Cell Biology Annual Meeting
    • Place of Presentation
      Philadelphia
    • Year and Date
      20101200
  • [Presentation] Maintenance of dendritic spine morphology by PAR1b through regulation of microtubule dynamics.2010

    • Author(s)
      林健二, 鈴木厚, 大野茂男
    • Organizer
      第33回日本分子生物学会年会 第83回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      20101200
  • [Presentation] KIBRA suppresses apical exocytosis through inhibition of aPKC kinase activity in epithelial cells.2010

    • Author(s)
      Yoshihama Y, Sasaki K, Horokoshi Y, Ohtsuka T, Hakuno F, Takahashi S-I, Suzuki A, Ohno S, Chida K
    • Organizer
      第33回日本分子生物学会年会 第83回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      20101200
  • [Presentation] 細胞極性による Hippo 経路の抑制がマウス着床前胚における位置依存的な細胞分化をつかさどる2010

    • Author(s)
      平手良和, 平原志乃, 井上健一, 中尾和貴, 鈴木厚, 秋本和憲, 大野茂男, 平井孝明, 千田和広, Marikawa Y, Vernadeth A, 佐々木洋
    • Organizer
      第33回日本分子生物学会年会 第83回日本生化学会大会 合同大会(口頭発表)
    • Place of Presentation
      神戸
    • Year and Date
      20101200
  • [Presentation] 新規PAR1 結合タンパク質p250 は,微小管安定化タンパク質である2010

    • Author(s)
      鈴木厚, 佐藤由典, 秋津真志, 天野芳子, 大野茂男
    • Organizer
      第62回日本細胞生物学会大会
    • Place of Presentation
      大阪市
    • Year and Date
      20100500
  • [Presentation] Intracellular polarity protein PAR-1 regulates extracellular laminin assembly by regulating the dystroglycan complex.2009

    • Author(s)
      A.Suzuki, K.Yamashita, Y.Amano, M. Masuda-Hirata, S.Ohno
    • Organizer
      American Society for Cell Biology 49th Annual Meeting
    • Place of Presentation
      San Diego, CA
    • Year and Date
      20091200
  • [Presentation] Interaction between PAR-3 and the aPKC-PAR-6 Complex Is Indispensable for Apical Domain Development of Epithelial Cells.2009

    • Author(s)
      堀越洋輔, 鈴木厚, 山中智行, 佐々木和教, 水野恵子, 米村重信, 大野茂男
    • Organizer
      The American Society for Cell Biology /Japan Society for Cell Biology /RIKEN Center for Developmental Biology Meeting
    • Place of Presentation
      Kyoto
    • Year and Date
      20090900
  • [Presentation] PAR-1/MARK Regulates Extracellular Laminin Assembly by Controling the Dystroglycan Complex.2009

    • Author(s)
      A.Suzuki, K.Yamashita, Y.Amano, M. Hirata, S.Ohno
    • Organizer
      The American Society for Cell Biology /Japan Society for Cell Biology /RIKEN Center for Developmental Biology Meeting
    • Place of Presentation
      Kyoto
    • Year and Date
      20090900
  • [Presentation] 細胞内極性タンパク質,PAR-1 はジストログリカン複合体を制御することによって,細胞外のラミニンの集積を制御している2009

    • Author(s)
      鈴木厚, 平田真樹, 天野芳子, 山下和成, 大野茂男
    • Organizer
      第61回日本細胞生物学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      20090600
  • [Presentation] PAR-3 とaPKC-PAR-6 との相互作用は,上皮細胞のアピカルドメインの形成に必要である2009

    • Author(s)
      堀越洋輔, 鈴木厚, 山中智行, 佐々木和教, 水野恵子, 米村重信, 大野茂男
    • Organizer
      第61回日本細胞生物学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      20090600
  • [Presentation] 円柱様上皮細胞の形態に必須な新規PAR-1b 結合タンパク質2009

    • Author(s)
      秋津真志, 鈴木厚, 山下和成, 天野芳子, 井出真理子, 大野茂男
    • Organizer
      第61回日本細胞生物学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      20090600
  • [Presentation] 細胞極性制御キナーゼPAR-1b は,utrophin のspectrin repeat ドメインと相互作用することで,utrophin- dystroglycan 複合体を安定化する2009

    • Author(s)
      山下和成, 鈴木厚, 井出真理子, 天野芳子, 林由起子, 平田真樹, 嶋田香子, 大野茂男
    • Organizer
      第61回日本細胞生物学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      20090600
  • [Presentation] aPKC は,円周性アクトミオシンバンドルの収縮をアンタゴナイズすることによって上皮細胞の接着結合の発達に必須な役割を果たしている2008

    • Author(s)
      岸川優, 鈴木厚, 大野茂男
    • Organizer
      第60回日本細胞生物学会大会
    • Place of Presentation
      横浜, 日本
    • Year and Date
      20080629-20080701
  • [Remarks] ホームページ等

    • URL

      http://www-user.yokohama-cu.ac.jp/~ohnos/Japanease/indexJ.html

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Published: 2012-01-26   Modified: 2016-04-21  

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