2010 Fiscal Year Final Research Report
Identification and structural analysis of chromatin boundary present nuclear peripheral region
| Project/Area Number |
20570188
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | University of Hyogo |
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Principal Investigator |
HIROSE Fumiko University of Hyogo, 大学院・生命理学研究科, 准教授 (60208882)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 転写因子 / クロマチン / SUMO |
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| Research Abstract |
We identified two novel factors which interact with hDREF. One of these factors was localized periphery of nuclei and nucleoli and might be a key molecule to identify factors responsible for maintenance or formation of chromatin boundary at nuclear periphery. We also demonstrated that hDREF possesses SUMO E3 ligase activity and could specifically SUMOylates the C-terminal region of Mi-2α, a component of NuRD complex and lamin A/C.
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