2010 Fiscal Year Final Research Report
Organization of Endoplasmic reticulum exit sites
| Project/Area Number |
20570190
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
TANI Katsuko Tokyo University of Pharmacy and Life Science, 生命科学部, 教授 (40266896)
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| Co-Investigator(Kenkyū-buntansha) |
ARIMITSU Nagisa 東京薬科大学, 生命科学部, 助教 (40408688)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 生体膜 |
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| Research Abstract |
The ER exit site (ERES) is an ER subdomain, in which COPII-coated vesicles are formed. To elucidate the organization and functions of the ERES, we analyzed three components localized in the ERES, p125 and Sec16A and B. We generated p125-KO mice and found that p125 is required for spermiogenesis. We also demonstrated that Sec16B, but not Sec16A, is involved in the protein transport from the ER to peroxisomes.
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Research Products
(13 results)
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[Journal Article] p125/Sec23-interacting protein (Sec23ip) is required for spermiogenesis.
Author(s)
Arimitsu N., Kogure T., Baba T., Nakao K., Hamamoto H., Sekimizu K., Yamamoto A., Nakanishi H., Taguchi R., Tagaya M., Tani K.
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Journal Title
Peer Reviewed
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