2010 Fiscal Year Final Research Report
Analyses of the fine-tuning mechanism of Arf6 activity on reorganization of epithelial organ
| Project/Area Number |
20570192
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Ehime University |
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Principal Investigator |
YANO Hajime Ehime University, 大学院・医学系研究科, 准教授 (00284414)
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| Project Period (FY) |
2008 – 2010
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| Keywords | Arf6 / 神経膠腫浸潤 / 浸潤抑制剤 / コンドロイチン硫酸プロテオグリカンNG2 |
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| Research Abstract |
Arf6 was previously proposed to be critical for epithelial cancer invasion. In this study, possible participation of one of the chondroitin sulfate proteoglycan NG2 at the upstream of Arf6 in glioma invasion was presented. Moreover, a signal mediated by sodium ion/proton exchanger 1 (NHE-1) was found to play a pivotal role in glioma cell invasion, independently of the Arf6 signal. These results implicate simultaneous inhibition of the both signals as effective therapeutic protocol for anti-invasion therapy of glioma.
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