2010 Fiscal Year Final Research Report
The molecular mechanisms of cellular aging and inhibition of cell growth mediated by transcription factor JDP2.
| Project/Area Number |
20570193
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
NAKADE Koji The Institute of Physical and Chemical Research, 遺伝子材料開発室, 協力研究員 (20392053)
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| Co-Investigator(Kenkyū-buntansha) |
PAN Jhanzhi 独立行政法人理化学研究所, 遺伝子材料開発室, 専任研究員 (80373356)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 老化 / 細胞増殖 / 酸化ストレス / 転写 / エピジェネシス / セネッセンス / p16Ink4a |
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| Research Abstract |
We have analyzed the molecular mechanisms of JDP2 in the regulation of cellular aging. We found that JDP2 induces the release of the histone methyltransferases, PRC1 and PRC2, from the p16Ink4a locus in response to oxidative stress, resulting the demethylation of histone H3 lysine 27 residue. This demethylation of histone causes the up-regulation of p16Ink4a and Arf, which are silenced by epigenetic effect in young cells. Finally, the cells are aged with senescent morphology.
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Research Products
(12 results)
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[Journal Article] Suppression of cell-cycle progression by Jun dimerization protein-2 (JDP2) involves downregulation of cyclin-A2.2010
Author(s)
Pan, J., K.Nakade, Y.C.Huang, Z.W.Zhu, S.Masuzaki, H.Hasegawa, T.Murata, A.Yoshiki, N.Yamaguchi, C.H.Lee, W.C.Yang, E.M.Tsai, Y.Obata, K.K.Yokoyama
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Journal Title
Oncogene 29(47)
Pages: 6245-56
Peer Reviewed
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[Journal Article] The ubiquitously expressed bZIP inhibitor, JDP2, suppresses the transcription of its homologue immediate early gene counterpart, ATF3.2009
Author(s)
Weidenfeld-Baranboim, K., T.Hasin, I.Darlyuk, R.Heinrich, O.Elhanani, J.Pan, K.K.Yokoyama, A.Aronheim
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Journal Title
Nucleic Acids Res 37(7)
Pages: 2194-203
Peer Reviewed
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[Journal Article] Role of histone chaperone JDP2 in replicative senescence.2009
Author(s)
Nakade, K., Pan, J, T.Yamasaki, M.Noguchi, S.Masuzaki, S.Kishikawa, T.Murata, Z.W.Zhu, X.Y.Chen, H.Hasegawa, N.Yamaguchi, E.M.Tsai, J.N.Lee, K.K.Yokoyama
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Journal Title
Current Topics in Biochemical Research 11(1)
Pages: 75-97
Peer Reviewed
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