2010 Fiscal Year Final Research Report
Analysis of neural and blood vessel network development in zebrafish mutant
| Project/Area Number |
20570195
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Tohoku University |
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Principal Investigator |
SHOJI Wataru 東北大学, 加齢医学研究所, 助教 (40250831)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 器官形成 / 神経 / 血管 |
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| Research Abstract |
We identified zebrafish mutant that has defect in blood vessels and neural network development. The mutated gene encodes an enzyme on cholesterol synthesis, and geranyl-geranyl products, which derive from intermediate metabolite of this pathway, was proved to be essential for blood vessels and neural development. Prenyl modification activates numbers of small G proteins, and we found rab family members are important in blood vessel development. We are further investigating what and how specific members of this gene family are involved in blood vessel development.
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Research Products
(21 results)
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[Journal Article] Islet1 selectively promotes peripheral axon outgrowth in Rohon-Beard primary sensory neurons2011
Author(s)
Tanaka, H., Nojima, Y., Shoji, W., Sato, M., Nakayama, R., Ohshima, T., Okamoto, H
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Journal Title
Developmental. Dynamics
Volume: 240
Pages: 9-22
Peer Reviewed
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[Journal Article] Crucial role of peroxiredoxin III in placental antioxidant defense of mice2008
Author(s)
Li, L., Shoji, W., Oshima, H., Obinata, M., Fukumoto, M., Kanno, N
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Journal Title
FEBS Lett
Volume: 582
Pages: 2431-2434
Peer Reviewed
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