Molecular mechanism of biological timer-determination mechanism of pupation timing of Drosophila-

2010 Fiscal Year Final Research Report

• Project/Area Number: 20570204
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Developmental biology
• Research Institution: Okayama University
• Principal Investigator: UEDA Hitoshi Okayama University, 大学院・自然科学研究科, 教授 (60201349)
• Project Period (FY): 2008 – 2010
• Keywords: 発生 / ショウジョウバエ / タイミング / タイマー / エクダイソン / 蛹化

Research Abstract

We uncovered mechanism to determine the termination of Blimp-1 expression which is important to determine the pupation timing in Drosophila. We also found that expression level and stability of Blimp-1 are important factor to determine the pupation timing and Blimp-1 works as sands in hourglass. Furthermore, we found that this timer system proceeds almost the same speed in different organs, but the speed is slightly different depending organs.

Research Products

• [Journal Article] Regulatory mechanisms of ecdysone-inducible Blimp-1 encoding a transcriptional repressor that is important for the prepupal development in Drosophila (2011)
  • Author(s): Kazutaka Akagi, Hitoshi Ueda
  • Journal Title: Development, Growth & Differentiation Vol, in press.
• [Presentation] A transcriptional repressor Blimp-1 works as an hourglass timer during metamorphosis. (2010)
  • Author(s): Kazutaka Akagi, Moustafa Sarhan, Hitoshi Ueda
  • Organizer: 51^<st> Annual Drosophila Research Conference, USA
  • Place of Presentation: Washington DC.
  • Year and Date: 20100407-20100411
• [Presentation] A transcriptional repressor Blimp-1 works as an hourglass timer during metamorphosis-Determination mechanism of pupation timing by transcription factors-. Ecdysone workshop (2010)
  • Author(s): Kazutaka Akagi, Moustafa Sarhan, Hitoshi Ueda
  • Organizer: 51^<st> Annual Drosophila Research Conference, USA
  • Place of Presentation: Washington DC.
  • Year and Date: 20100407-20100411
• [Presentation] A transcriptional repressor Blimp-1 works as an hourglass timer during (2010)
  • Author(s): Kazutaka Akagi, Moustafa Sarhan, Hitoshi Ueda
  • Organizer: Drosophila metamorphosis, DECODE Winter Workshop 2010
  • Place of Presentation: Yuzawa.
  • Year and Date: 20100118-20100120
• [Presentation] Mechanism to determine pupation timing during prepupal period in Drosophila (2010)
  • Author(s): Hitoshi Ueda
  • Organizer: 18th International Ecdysone Workshop
  • Place of Presentation: Ceske Budejovice, Czech.
  • Year and Date: 2010-07-20
• [Presentation] A transcriptional repressor Blimp-1 works as an hourglass timer to determine pupation timing in Drosophila (2009)
  • Author(s): Kazutaka Akagi, Moustafa Sarhan, Hitoshi Ueda
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 20091209-20091212
• [Presentation] A transcriptional repressor Blimp-1 works as an hourglass in a biological timer system to determine pupation timing in Drosophial (2009)
  • Author(s): Moustafa Sarhan, Kazutaka Akagi, Hitoshi Ueda
  • Organizer: The 9^<th> Japanese Drosophila Research Conference
  • Place of Presentation: Kakegawa.
  • Year and Date: 20090706-20090708
• [Presentation] The importance of controlled expression of the transcriptional repressor Blimp-1 in a biological timer system to determine pupation timing in Drosophila melanogaster (2009)
  • Author(s): Kazutaka Akagi, Moustafa Sarhan, Hitoshi Ueda
  • Organizer: 50^<th> Annual Drosophila Research Conference
  • Place of Presentation: Chicago, USA.
  • Year and Date: 20090304-20090308
• [Presentation] ショウジョウバエの蛹化のタイミングを決める生物タイマーにおける転写抑制因子Blimp-1の発現制御の重要性 (2008)
  • Author(s): 赤木一考、Moustafa Sarhan、上田均
  • Organizer: 第31回日本分子生物学会年会/第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 20081209-20081212
• [Presentation] Regulatory mechanism of temporal expression of Blimp-1, an important factor for determination of pupation timing (2008)
  • Author(s): Kazutaka Akagi, Hitoshi Ueda
  • Organizer: 49^<th> Annual Drosophila Research Conference
  • Place of Presentation: San Diego, USA.
  • Year and Date: 20080402-20080406
• [Presentation] Regulation mechanism of the Blimp-1 gene which plays an important role to determine pupation timing (2008)
  • Author(s): Kazutaka Akagi, Moustafa Sarhan, Hitoshi Ueda
  • Organizer: Ecdysone workshop
  • Place of Presentation: San Diego, USA.
  • Year and Date: 2008-04-02