2010 Fiscal Year Final Research Report
Coupled role of Nodal and Notch in the establishment of mesodermal tissue
| Project/Area Number |
20570212
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Rikkyo University |
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Principal Investigator |
KINOSHITA Tsutomu Rikkyo University, 理学部, 教授 (30161532)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Masahiro 立教大学, 理学部, 助教 (00360660)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 胚葉形成 / 原腸形成 / 体節形成 |
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| Research Abstract |
In early development of Xenopus embryo, Nodal signaling induces ring-shaped mesodermal tissue in the marginal zone of gastrula embryo. To understand the molecular mechanism determining the mesoderm area, transcriptional network was examined during the mesodermal formation. Several lines of experiments showed that Nodal signaling regulates the boundary formation and the cell phase transition from growth to differentiation in the mesodermal tissue by coupling with Notch signaling.
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