2010 Fiscal Year Final Research Report
Functional difference between Notch ligands Dll1 and Dll3 in mouse somitogenesis
| Project/Area Number |
20570215
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
TAKAHASHI Yu National Institute of Health Sciences, 毒性部, 室長 (60321858)
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| Co-Investigator(Renkei-kenkyūsha) |
KITAJIMA Satoshi 国立医薬品食品衛生研究所, 毒性部, 室長 (30270622)
YASUHIKO Yukuto 国立医薬品食品衛生研究所, 毒性部, 主任研究官 (40370944)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 体節形成 / Notchシグナル / マウス / 遺伝学 |
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| Research Abstract |
We generated a Dll3-knockin mouse, which express Dll3 instead of Dll1, and analyzed effects on somitogenesis and molecular clock mechanism. Our results suggested that Dll3 is not a Notch ligand but acts as a suppressive modulator. In addition, these mice showed segmentation of vertebral body without Notch signal oscillation, implying presence of another mechanism.
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