2010 Fiscal Year Final Research Report
Molecular evolution of microRNA gene families
| Project/Area Number |
20570222
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Evolutionary biology
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| Research Institution | Kagawa University |
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Principal Investigator |
IWAMA Hisakazu Kagawa University, 総合生命科学研究センター, 准教授 (20398035)
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| Project Period (FY) |
2008 – 2010
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| Keywords | マイクロRNA / 遺伝子族 / ターゲット配列 / 遺伝子制御網 / オルソログ / 冗長性 / 協調的遺伝子制御 / フィードフォワード回路 |
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| Research Abstract |
MicroRNA (miRNA) gene families are shown to have evolved to alter their network configurations so that they increase the network redundancy and, in contrast, reduce their target gene repertoire. These findings suggest that a large part of the redundancy-adding role of miRNA gene families is attributable to non-adaptive processes of avoiding conflicts with the established transcription factor regulatory networks. This further indicates that the high redundancy in the miRNA regulatory networks is not necessarily a hallmark of adaptive roles such as robustness, failsafe or fine-tuning.
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