2010 Fiscal Year Final Research Report
The molecular mechanism of Golgi cisternal maturation
| Project/Area Number |
20580073
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NODA Yoichi The University of Tokyo, 農学生命科学研究科, 助教 (90282699)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 微生物機能 / 出芽酵母 / 小胞輸送 |
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| Research Abstract |
We found that Svp26, a yeast ER-Golgi resident membrane protein, is involved in the Golgi localization of the N-mannosyltransferases Mnn2 and Mnn5, and the O-mannosyltransferases Ktr3, Kre2 and Ktr1. We also found the membrane proteins involved in the Golgi localization of Ktr4, whose Golgi localization is independent of Svp26. We found that mannosyltransferases display distinct detergent solubility.
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