2010 Fiscal Year Final Research Report
Analysis of novel stress responses in Corynebacterium glutamicum
| Project/Area Number |
20580085
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Tokyo Denki University |
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Principal Investigator |
NAKAMATSU Tsuyoshi Tokyo Denki University, 工学部, 教授 (40339065)
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| Co-Investigator(Kenkyū-buntansha) |
KAWASAKI Hisashi 東京電機大学, 工学部, 教授 (90349788)
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| Project Period (FY) |
2008 – 2010
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| Keywords | コリネバクテリウム グルタミカム / Corynebacterium glutamicum / ストレス応答アミノ酸発酵 |
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| Research Abstract |
We analyzed 7 genes that are upregulated when glutamate overproduction is induced in Corynebacterium glutamicum. Our results suggested that 3 genes-NCgl2944, NCgl2945, and NCgl2946-were responsible for not only coping with the stress that induced the overproduction of glutamate but also growth in a synthetic medium. Further, we found significantly increased activities of 3 enzymes that catalyze reactions directly connected with the central carbon metabolism.
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