2010 Fiscal Year Final Research Report
Basic study for development of a recombinat vaccine using Bacillus subtilis
| Project/Area Number |
20580089
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Setsunan University |
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Principal Investigator |
TAKAMATSU Hiromu Setsunan University, 薬学部, 准教授 (70272151)
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| Co-Investigator(Kenkyū-buntansha) |
KUWANA Ritsuko 摂南大学, 薬学部, 助教 (50330361)
IMAMURA Daisuke 摂南大学, 薬学部, 助教 (70454650)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 微生物利用学 |
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| Research Abstract |
Bacillus subtilis is a non-toxigenic bacterium wich is widely used in industry. We found that CgeA and CotZ proteins locating on the outermost layer of B. subtilis spores by means of fluorescent microscopy. The GFP fusions of CgeA and CotZ assembled onto recombinant spores reacted with anti-GFP antibody. These results suggest that CgeA and CotZ are suitable as carrier proteins to display an antigen on a recombinant spores vaccine.
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Research Products
(8 results)
