2010 Fiscal Year Final Research Report
The molecular mechanism underlying the co-regulation of plasma membrane and F-actin
| Project/Area Number |
20580096
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
IHARA Sayoko 東京大学, 大学院・農学生命科学研究科, 助教 (80292788)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 細胞応答 |
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| Research Abstract |
Cells change their morphology under various physiological conditions. Co-regulation of plasma membrane and cytoskeleton is required for these changes, the mechanism of which is not fully understood. We addressed the issue by functional analysis of SWAP-70, which binds to both membrane and actin in a stimulus-dependent way. We found that SWAP-70 binds to integrin. 1 in a pull down assay, and the activation of integrin. 1 rescued SWAP-70-deficient phenotype, suggesting that SWAP-70 may function by activating integrin. 1 through their interaction.
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