2010 Fiscal Year Final Research Report
Study on the interactions between animal lectins and carbohydrate chains based on their three-dimensional structures
| Project/Area Number |
20580100
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UNNO Hideaki 長崎大学, 大学院・工学研究科, 助教 (10452872)
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| Project Period (FY) |
2008 – 2010
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| Keywords | レクチン / 糖鎖 / X線結晶構造解析 / 部位特異的変異 / 分子認識 |
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| Research Abstract |
Interactions between carbohydrate-binding proteins (lectins) and carbohydrate chains were analyzed based on their three-dimensional structures. The results demonstrated that that various carbohydrate chains can be recognized by combinations of amino acid residues located in the binding sites of lectins, which provides useful information to design novel molecular-recognition proteins. In addition, it was also revealed that binding of carbohydrates to lectin may induce conformational changes, which lead further biological activities to cells.
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[Journal Article] Mitogenic activity of CEL-I, an N-acetylgalactosamine (GalNAc)-specific C-type lectin, isolated from the marine invertebrate Cucumaria echinata (Holothuroidea), Bioscience2010
Author(s)
Zedong Jiang, Daekyung Kim, Yasuhiro Yamasaki, Tomohiro Yamanishi, Tomomitsu Hatakeyama, Kenichi Yamaguchi, Tatsuya Oda
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Journal Title
Biotechnology, and Biochemistry 74(8)
Pages: 1613-1616
Peer Reviewed
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