2010 Fiscal Year Final Research Report
Regulation of osteoclastogenesis by protein phosphatase 2C
| Project/Area Number |
20580105
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Chubu University |
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Principal Investigator |
OHNISHI Motoko Chubu University, 応用生物学部, 教授 (00312653)
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| Co-Investigator(Kenkyū-buntansha) |
WOO JaeーTae 中部大学, 応用生物学部, 教授 (20272693)
NAGAI Kazuo 中部大学, 応用生物学部, 教授 (00011974)
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| Project Period (FY) |
2008 – 2010
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| Keywords | プロテインホスファターゼ / 破骨細胞 / 破骨細胞分化因子 / シグナル伝達 |
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| Research Abstract |
Bone continuously undergoes remodeling, in which bone resorption by osteoclasts is followed by bone formation by osteoblasts, and maintains its structure and function. An imbalance in the regulation of bone remodeling results in many metabolic bone diseases, such as osteoporosis. Here we show that a low molecular weight compound which specifically activates protein phosphatase 2C(PP2C)suppressed osteoclastogenesis, and how it acts on the RANKL induced osteoclast differentiation.
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[Journal Article] a β-carboline alkaloid, inhibits osteoclast differentiation and bone resorption in vitro and in vivo.2011
Author(s)
Yonezawa T, Hasegawa S, Asai M, Ninomiya T, Sasaki T, Cha BY, Teruya T, Ozawa H, Yagasaki K, Nagai K, Woo JT
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Journal Title
Eur J Pharmacol. 650(2-3)
Pages: 511-8
Peer Reviewed
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[Journal Article] Identification of oxytetracycline as a chondrogenic compound using a cell-based screening system.2010
Author(s)
Hojo H, Yano F, Ohba S, Igawa K, Nakajima K, Komiyama Y, Kan A, Ikeda T, Yonezawa T, Woo JT, Takato T, Nakamura K, Kawaguchi H, Chung UI
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Journal Title
J Bone Miner Metab. 28(6)
Pages: 627-33
Peer Reviewed
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[Journal Article] Alisol-B, a novel phyto-steroid, suppresses the RANKL-induced osteoclast formation and prevents bone loss in mice.2010
Author(s)
Lee JW, Kobayashi Y, Nakamichi Y, Udagawa N, Takahashi N, Im NK, Seo HJ, Jeon WB, Yonezawa T, Cha BY, Woo JT
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Journal Title
Biochem Pharmacol. 80
Pages: 352-361
Peer Reviewed
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[Journal Article] Development of high-throughput screening system for osteogenic drugs using a cell-based sensor.2008
Author(s)
Hojo H, Igawa K, Ohba S, Yano F, Nakajima K, Komiyama Y, Ikeda T, Lichtler AC, Woo JT, Yonezawa T, Takato T, Chung UI
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Journal Title
Biochem Biophys Res Commun. 376(2)
Pages: 375-9
Peer Reviewed
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