2010 Fiscal Year Final Research Report
Synthetic and bioorganic studies on sarcodonins
| Project/Area Number |
20580110
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Shinshu University |
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Principal Investigator |
MAKABE Hidefumi Shinshu University, 農学研究科, 准教授 (90313840)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 有機化学 / 合成化学 / 生理活性 |
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| Research Abstract |
Synthetic studies on sarcodonin J and structural activity relationship study on sarcodonin A related compounds were performed. As to the synthetic study on sarcodonin J, synthetic route was almost accomplished using Negishi coupling starting from (-)-Wieland-Miescher ketone. As to the structural activity relationship study on sarcodonin A related compounds, the hydroxyl group at C-14 position proved to be extremely important for the anti-inflammatory activity.
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