2010 Fiscal Year Final Research Report
Mechanism for potentiation of drug-effects in mitochondrion-disturbing agents.
| Project/Area Number |
20580113
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Bioproduction chemistry/Bioorganic chemistry
|
|---|
| Research Institution | Osaka City University |
|---|
Principal Investigator |
FUJITA Ken-Ichi Osaka City University, 大学院・理学研究科, 准教授 (10285281)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | trans-anethole / PDR5遺伝子 / Candida albicans / fluconazole / 相乗的抗真菌作用 / 薬剤耐性 / 薬剤排出ポンプ / 出芽酵母 |
|---|
| Research Abstract |
Dodecanol exhibits temporary fungicidal activity against budding yeast. In this study, we investigated expression mechanism for the durable fungicidal activity of a mitochondrion-disturbing agent, anethole, combined with dodecanol. In dodecanol-treated cells of S. cerevisiae, increase in the gene expression of PDR5 among ABC transporters was detected. On the other hand, in cells treated with dodecanol and anethole, over-expression of PDR5 gene was restricted. These results indicated anethole expressed durable fungicidal activity via restriction of PDR5 gene expression.
|
