2010 Fiscal Year Final Research Report
Fine chemical production by complementary use of microbial catalysts and organic synthesis
| Project/Area Number |
20580114
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Keio University |
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Principal Investigator |
SUGAI Takeshi Keio University, 薬学部, 教授 (60171120)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 有機化学 / バイオリアクター / 酵素 / 応用微生物 |
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| Research Abstract |
On the screening of biocatalysts for the key steps in the total synthetic schemes, molecular design of substrates for enzyme-catalyzed reactions was thoroughly elaborated. Practical synthetic schemes themselves approaching key intermediates were also studied. As the results, three major methods for preparation were achieved : 1) the exploration of hydrolyzing enzymes which regioselectively treat the hydroxy and acyloxy groups in glycal derivatives ; 2) development of new functions of an epoxide hydrolase through the substrate specificity study ; 3) synthesis of the unique fluorine-containing aromatic substances which probe the recognition of remote chirality in the catalytic site of lipases. Based on them, novel and expeditious synthetic routes for sialidase inhibitors and a chiral analyzing agent for trace amount of biomolecules were established.
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[Journal Article] Chemo-enzymatic Synthesis of Both Enantiomers of 2-tert-Butyl-2-methyl-1,3-benzodioxole-4-car boxylic (TBMB) Acid2010
Author(s)
T.Higashi, C.Abe, K.Ninomiya, T.Machida, N.Chishima, S.Taketomi, M.Furuta, Y.Komaki, Y.Senba, T.,Tokuda M.Shoji, T.Sugai
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Journal Title
Adv.Synth.Catal. 352
Pages: 2549-2558
Peer Reviewed
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