2011 Fiscal Year Final Research Report
Liquid-phase combinatorial synthesis of biologically active peptides utilizing fluorous tag
| Project/Area Number |
20580115
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Meijo University |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2011
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| Keywords | フルオラス / 液相コンビナトリアル合成 / 生理活性 / ペプチド |
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| Research Abstract |
A study to carry out a concise liquid combinatorial synthesis of bioactive peptides, which was encoded by fluorous tag, was conducted. We have developed a highly active condensation reagent for peptides coupling, and a large-scale synthetic method of the fluorous protecting-reagent for amino acids. Furthermore, a synthetic route of Tenuecyclamide B from the N-terminus was established for the liquid mixture synthesis of the all stereoisomers.
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