2010 Fiscal Year Final Research Report
Molecular modeling of food-grade compounds with anti-conformational disease effects by using amyloidogenic proteins
| Project/Area Number |
20580124
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Shinshu University |
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Principal Investigator |
NAKAMURA Soichiro Shinshu University, 農学部, 教授 (00105305)
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| Co-Investigator(Kenkyū-buntansha) |
TERASHIMA Shoji 東海学園大学, 人間健康学部, 教授 (40227517)
FUJII Hiroshi 信州大学, 農学部, 教授 (90165340)
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| Project Period (FY) |
2008 – 2010
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| Keywords | アミロイド線維形成 / 天然フェノール化合物 / フェノール化合物誘導体 / 分子モデリング / リポフィル化 / グリコシル化 / アミロイド型蛋白質 / 抗アミロイド効果 |
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| Research Abstract |
Anti-conformational disease effects of naturally-occurring phenolic compounds and their glycosyl and lipophilic derivatives were investigated by using amyloidogenic proteins containing cystatin C L68Q variant and A β which are responsible for hereditary cystatin C amyloid angiopathy and Alzheimer's disease, respectively. As the result, it was revealed that lyophilization was more effective than glycosylation for improving anti-amyloidgenicity of the tested phenolic compounds. These observations regarding conformation-functional relationship can be useful for novel inhibitors' design as therapeutic agents for amyloid-associated diseases.
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Research Products
(26 results)
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[Book] Amyloidogenic proteins and peptides(Bioactive proteins and peptides as functional foods and nutraceuticals)(In : Mine, Y., Li-Chan, Y., Bo, J.(ed))2010
Author(s)
Soichiro Nakamura, Takanobu Owaki, Yuki Maeda, Shigeru Katayama, Kosuke Nakamura
Total Pages
87-99
Publisher
Blackwell Publishing Ltd, New York
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[Remarks] 信大生に奨励賞,農芸化学会支部で研究発表,ボリフエノールを検証,農学部4年小川さん,2009.10.6,信濃毎日新聞
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[Remarks] 信州大学大学院農学研究科の近藤さん,カナダのシンポ学生優秀賞に,蛋白質研究のポスター発表で「とてもうれしい」,2009.9.4,信濃毎日新聞
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[Remarks] 信州大学大学院の近藤さん,国際シンポで優秀発表賞,フエノール新たに合成,認知症の予防治療に効果も,2009.9.3,中日新聞
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[Remarks] 日本農芸化学会中部支部の奨励賞,信大院生3人受賞,農学研究科の探究心に刺激,それぞれの研究を振り返る大脇さん,鈴木さん,飯島さん,2008.11.15,信濃毎日新聞
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