2010 Fiscal Year Final Research Report
Roles of adipocytokines in colorectal carcinogenesis and identification of preventive food factors
| Project/Area Number |
20580129
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kyoto University |
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Principal Investigator |
MURAKAMI Akira Kyoto University, 大学院・農学研究科, 助教 (10271412)
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| Project Period (FY) |
2008 – 2010
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| Keywords | メタボリックシンドローム / 肥満 / レプチン / インスリン / 大腸発がん / ノビレチン / 脂肪細胞 / 柑橘類 |
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| Research Abstract |
At present, obesity is trending in many developed countries, and there is increasing evidence that obesity is associated with colorectal carcinogenesis. In the present study, I attempted to identify endogenous factors which are concomitantly regulated in the processes of obesity and colorectal cancer. Leptin was suggested to be important hormone that increased during chemical carcinogenesis in the colon. In addition, citrus nobiletin was identified to be a promising phytochemical that is capable of regulating leptin levels appropriately and preventing colon tumorigenesis in mice.
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