2010 Fiscal Year Final Research Report
Molecular mechanisms of neuropathy caused by vitamin B12-deficiency in elderly people
| Project/Area Number |
20580132
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Tottori University |
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Principal Investigator |
WATANABE Fumio Tottori University, 農学部, 教授 (30210941)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 栄養生化学 / ビタミン学 |
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| Research Abstract |
To elucidate the molecular mechanisms of neuropathy caused by vitamin B12-deficiency in elderly people, the vitamin-deficient nematode (Caenorhabditis elegans) was prepared and used as a model animal. The vitamin B12-deficient nematode showed significant metabolic disorders of lipids and amino acids, and accumulation of oxidative stress ; such disorders result in inefficiency of neurotransmission, functional disturbance of neuron receptors, and death of neuron.
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