2010 Fiscal Year Final Research Report

Study on molecular mechanisms by which sweet constituents of Siraitia grosvenori exert anti-diabetes and anti-arteriosclerosis effects

Research Project

Project/Area Number	20580140
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Food science
Research Institution	Osaka Prefecture University
Principal Investigator	INUI Hiroshi Osaka Prefecture University, 生命環境科学研究科, 教授 (20193568)
Project Period (FY)	2008 – 2010
Keywords	ラカンカ / モグロシド / 抗糖尿病作用 / 動脈硬化予防作用 / インスリン膵臓β細胞 / 抗酸化作用 / 体内動態
Research Abstract	Siraitia grosvenori, a traditional Chinese fruit used for a folk medicine, contains mogroside V, one of triterpene glycosides, and has been commercially available as a low-calorie sweetener for over-weight people and diabetic patients. In this study, the anti-diabetic effect of this fruit was examined, and it was found that mogrol, which is the aglycon of mogroside V, stimulated insulin secretion from pancreatic β-cells in vitro. From the aspect of anti-arteriosclerosis effect, it was elucidated that the extract of this fruit prevented oxidative stress induced by cholesterol loading in rats. In addition, the digestion, absorption, and disposition of mogroside V and its aglycon were also examined.