2010 Fiscal Year Final Research Report
Analysis of peanut allergen with human monoclonal antibodies
| Project/Area Number |
20580143
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Tamagawa University |
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Principal Investigator |
SHINMOTO Hiroshi Tamagawa University, 農学部, 教授 (50355301)
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| Research Collaborator |
SOHEILA J.Maleki 米国農務省農業研究所南部研究センター
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| Project Period (FY) |
2008 – 2010
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| Keywords | 食物アレルギー |
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| Research Abstract |
Peripheral blood B-cells were transformed with Epstein-Barr virus. We have obtained 31 oligo-clonal B-cells secreting antibodies recognizing 6 parts or peanut allergen Ara h1 protein. Detailed analysis with human IgM class monoclonal antibodies 92-2 and #86 against peanut allergen Ara h1 showed that the peptides QEWGTPGS and DEDEEEE were core epitopes of Ara h1.
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