2010 Fiscal Year Final Research Report
Inhibitory mechanism of lenthionine against platelet aggregation and biological activity of its inclusion complex in α-cyclodextrin
| Project/Area Number |
20580145
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Nihon University |
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Principal Investigator |
KUMAGAI Hitomi Nihon University, 生物資源科学部, 准教授 (20225220)
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| Project Period (FY) |
2008 – 2010
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| Keywords | レンチオニン / 血小板凝集抑制 / リン酸化 / 膜タンパク質 / シクロデキストリン |
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| Research Abstract |
We analyzed the mechanism of the inhibitory effect of lenthionine, cyclic sulfuric flavor component in shiitake, against platelet aggregation. In addition, we attempted to reduce its odor and enhance its solubility in water by the inclusion of lenthionine in α-cyclodextrin. Lenthionine suppressed phospholylation of talin, morphological change in platelets, and activation of integrin αIIbβ3. Inclusion of lenthionine by α-cyclodextrin reduced its characteristic odor and enhanced its solubility in water. Lenthionine included in α-cyclodextrin inhibited platelet aggregation ex vivo.
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