2010 Fiscal Year Final Research Report
Activation of AMP-activated protein kinase using food factors
| Project/Area Number |
20580146
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Chubu University |
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Principal Investigator |
TSUDA Takanori Chubu University, 応用生物学部, 准教授 (90281568)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 糖尿病 / 肥満 / 食品因子 |
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| Research Abstract |
Recent studies show that AMP-activated protein kinase (AMPK) is one of the most important factors for cellular energy balance and is recognized as a potential therapeutic target in the prevention and treatment of type2 diabetes. Food factors can activate AMPK and this activation may potentially have anti-diabetic effects. Therefore, the present study was designed to examine whether the administration of food factors activate AMPK and reduces blood glucose level and improves insulin sensitivity in type2diabetic mice.
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[Journal Article] 6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-α mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes.2008
Author(s)
Y.Isa, Y.Miyakawa, M.Yanagisawa, T.Goto, M.S.Kang, T.Kawada, Y.Morimitsu, K.Kubota, T.Tsuda
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Journal Title
Biochem.Biophys.Res.Commun. 373
Pages: 429-434
Peer Reviewed
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